Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).
Bioorg Med Chem Lett
; 15(6): 1669-73, 2005 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-15745819
ABSTRACT
A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's).
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Base de dados:
MEDLINE
Assunto principal:
Dimetilaminas
/
Inibidores das Enzimas do Citocromo P-450
/
Imidazóis
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article