Potent and selective [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines as retinoic acid metabolic blocking agents (RAMBAs).

Mulvihill, Mark J; Kan, Julie L C; Beck, Patricia; Bittner, Mark; Cesario, Cara; Cooke, Andrew; Keane, David M; Nigro, Anthony I; Nillson, Christy; Smith, Vanessa; Srebernak, Mary; Sun, Feng-Lei; Vrkljan, Michael; Winski, Shannon L; Castelhano, Arlindo L; Emerson, David; Gibson, Neil

Mulvihill, Mark J; Kan, Julie L C; Beck, Patricia; Bittner, Mark; Cesario, Cara; Cooke, Andrew; Keane, David M; Nigro, Anthony I; Nillson, Christy; Smith, Vanessa; Srebernak, Mary; Sun, Feng-Lei; Vrkljan, Michael; Winski, Shannon L; Castelhano, Arlindo L; Emerson, David; Gibson, Neil.

Afiliação

Mulvihill MJ; OSI Pharmaceuticals, Inc., 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. mark.mulvihill@osip.com

Bioorg Med Chem Lett ; 15(6): 1669-73, 2005 Mar 15.

Article em En | MEDLINE | ID: mdl-15745819

ABSTRACT

ABSTRACT

A series of [2-imidazol-1-yl-2-(6-alkoxy-naphthalen-2-yl)-1-methyl-ethyl]-dimethyl-amines were designed and synthesized as CYP26 inhibitors, serving as retinoic acid metabolic blocking agents (RAMBA's).

Assuntos

Inibidores das Enzimas do Citocromo P-450; Dimetilaminas/química; Dimetilaminas/farmacologia; Imidazóis/química; Imidazóis/farmacologia; Animais; Antineoplásicos/química; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Sistema Enzimático do Citocromo P-450; Dimetilaminas/síntese química; Humanos; Imidazóis/síntese química; Masculino; Microssomos/enzimologia; Ratos; Ácido Retinoico 4 Hidroxilase

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Base de dados: MEDLINE Assunto principal: Dimetilaminas / Inibidores das Enzimas do Citocromo P-450 / Imidazóis Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2005 Tipo de documento: Article

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