Bilateral asymmetry in Chinese families with cleft lip with or without cleft palate.
Cleft Palate Craniofac J
; 42(2): 192-6, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15748111
ABSTRACT
OBJECTIVE:
To determine if Chinese individuals with nonsyndromic cleft lip with or without cleft palate (CL/P) display more bilateral asymmetry than do their unaffected relatives. DESIGN/SUBJECTS:
A case-control study of 313 individuals with CL/P from Shanghai, China, with 201 unaffected relatives as controls.METHODS:
Size-adjusted asymmetry scores were defined by data on middle-finger length, palm length, palpebral fissure width, and ear length. Case-control comparisons used a multivariate repeated measures analysis of variance, paired t tests, and the Wilcoxon signed rank test.RESULTS:
The ear-length measure showed a significant increase in fluctuating asymmetry (FA) in individuals with CL/P compared with their unaffected relatives, which was most pronounced in the female cleft lip and palate subgroup (p = .04). No other measures showed any increase in FA.CONCLUSION:
Evidence was found for increased FA, as measured by overall ear length, in Chinese individuals with nonsyndromic CL/P, compared with their unaffected family members. The use of bilateral measurements other than dermatoglyphics may prove to be a valuable means of assessing overall developmental stability in individuals with developmental malformations and in their families.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Pesos e Medidas Corporais
/
Fenda Labial
/
Fissura Palatina
/
Orelha Externa
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article