[Determination and pharmacokinetics of photosensitizer ZnPcS2P2 uptaken by K562 cells].
Guang Pu Xue Yu Guang Pu Fen Xi
; 24(11): 1415-8, 2004 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-15762492
ABSTRACT
The di-sulfonated di-phthalimidomethyl phthalocyanine zinc (ZnPcS2P2) was an amphiphilic photosensitizer for photodynamic therapy of cancer. According to fluorescence analytical method, extracting efficiencies of 2.0% SDS (Wt%), 1.5% Triton X-100 (phi) and DMF for ZnPcS2P2 in K562 cells were compared. The results showed that 1.5% Triton X-100 was the most efficient reagent for the first time extracting. Using 1.5% Triton X-100 as extracting reagent, the kinetic curves of cellular uptake of ZnPcS2P2 as well as LDL-ZnPcS2P2 complex by K562 cells were determined. Compared with ZnPcS2P2, the maximum cellular uptake of LDL-ZnPcS2P2 by K562 was doubled, which indicated that LDL was an effective targeting delivery vehicle for ZnPcS2P2.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Genes abl
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Fármacos Fotossensibilizantes
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Células K562
/
Indóis
Limite:
Humans
Idioma:
Zh
Ano de publicação:
2004
Tipo de documento:
Article