Genetic control of susceptibility to autoimmune gastritis.
Int Rev Immunol
; 24(1-2): 55-62, 2005.
Article
em En
| MEDLINE
| ID: mdl-15763989
ABSTRACT
A familial component to the tendency to develop autoimmune gastritis has long been recognized. Although linkage to certain HLA alleles and an association with the endocrine autoimmune diseases thyroiditis and type 1 diabetes have been reported, little further progress has been achieved in clinical studies. In contrast, the mouse model of gastritis induced in the BALB/c strain by thymectomy in the third day of life has identified four linkage regions; two on distal chromosome 4 (Gasa1 and Gasa2), one on chromosome 6 (Gasa3) and one in the H2 (Gasa4). Three of these four genes colocalize with NOD mouse diabetes susceptibility genes--the strongest concordance identified to date between any two autoimmune diseases--reflecting the association between autoimmune diabetes and type 1 gastritis in humans.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Predisposição Genética para Doença
/
Gastrite
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article