[Study on the relationship between genetic polymorphism Val384Asp in hMLH1 gene and the risk of four different carcinomas].
Zhonghua Liu Xing Bing Xue Za Zhi
; 25(11): 978-81, 2004 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-15769334
ABSTRACT
OBJECTIVE:
To investigate the association of genetic polymorphism Val384Asp in hMLH1 gene with the risk of colorectal, gastric, esophageal and breast carcinomas.METHODS:
A case-control study was taken to investigate the role of Val384Asp in hMLH1 gene in developing these four carcinomas. 233 colorectal, 273 gastric, 90 esophageal and 111 breast cancer patients were included, as well as 268 healthy individual served as controls. Peripheral white blood cell DNA was obtained from all subjects. hMLH1 gene Val384Asp was analysed using a PCR-based DHPLC while the existence of Val384Asp were verified by DNA sequencing.RESULTS:
6.34% of the healthy individuals were identified as Val384Asp carriers and significant differences existing between colorectal cancer patients or gastric cancer patients and controls, especially between young aged patients and controls.CONCLUSION:
Determination of Val384Asp in hMLH1 gene single nucleotide polymorphism seemed to be suitable for identifying individuals with increased risk of gastrointestinal cancer in the Chinese population.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Proteínas Nucleares
/
Proteínas de Transporte
/
Predisposição Genética para Doença
/
Mutação de Sentido Incorreto
/
Neoplasias do Sistema Digestório
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Ano de publicação:
2004
Tipo de documento:
Article