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Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Swanson, Devin M; Dubin, Adrienne E; Shah, Chandra; Nasser, Nadia; Chang, Leon; Dax, Scott L; Jetter, Michele; Breitenbucher, J Guy; Liu, Changlu; Mazur, Curt; Lord, Brian; Gonzales, Lisa; Hoey, Kenway; Rizzolio, Michele; Bogenstaetter, Michael; Codd, Ellen E; Lee, Doo H; Zhang, Sui-Po; Chaplan, Sandra R; Carruthers, Nicholas I.
Afiliação
  • Swanson DM; Johnson & Johnson Pharmaceutical Research and Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA.
J Med Chem ; 48(6): 1857-72, 2005 Mar 24.
Article em En | MEDLINE | ID: mdl-15771431
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Base de dados: MEDLINE Assunto principal: Piperazinas / Aminopiridinas / Analgésicos / Canais Iônicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2005 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Piperazinas / Aminopiridinas / Analgésicos / Canais Iônicos Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2005 Tipo de documento: Article