Difference in susceptibility to malaria between two sympatric ethnic groups in Mali.
Am J Trop Med Hyg
; 72(3): 243-8, 2005 Mar.
Article
em En
| MEDLINE
| ID: mdl-15772314
We compared malaria indicators among sympatric groups to study human heterogeneities in the response to Plasmodium falciparum malaria infection. Four cross-sectional surveys and two longitudinal surveys in two sympatric ethnic groups (Dogon and Fulani) in Mali were carried out from 1998 to 2000. Spleen and parasite rates were evaluated during the cross-sectional surveys and disease incidence was assessed during longitudinal surveys. In spite of similar sociocultural factors and entomologic inoculation rates between ethnic groups, the Fulani had a significantly higher spleen enlargement rate, lower parasite rate, and were less affected by the disease than the Dogon group, whose frequency of hemoglobin C was higher than that recorded among the Fulani group. The Fulani group had significantly higher levels of IgG and IgE against crude malaria antigen than the Dogon group, suggesting a role of anti-malaria antibodies in the immune protection seen in this group.
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Base de dados:
MEDLINE
Assunto principal:
Etnicidade
/
Malária Falciparum
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article