Tachykinin neuropeptides in cerebellar granule neurons: an immunocytochemical study.
Eur J Histochem
; 49(1): 87-92, 2005.
Article
em En
| MEDLINE
| ID: mdl-15823799
We previously demonstrated that exogenously administered neurokinin A and neurokinin B, but not substance P, increased the sensitivity of cultured cerebellar granule neurons (CGNs) to glutamate. In the present study, the presence of tachykinin neuropeptides in CGNs was tested by confocal-based immunofluorescence. We found that neurokinin A and neurokinin B are present in CGNs but absent in astrocytes while substance P is abundant in astrocytes but absent in CGNs. It is postulated that the different localization of tachykinin neuropeptides in CGNs and astroglial cells has a physiological role in the modulation of excitatory transmission.
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Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
/
Taquicininas
/
Cerebelo
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article