Experimental infection of prairie dogs with monkeypox virus.
Emerg Infect Dis
; 11(4): 539-45, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15829191
ABSTRACT
Studies of experimental infection of prairie dogs (Cynomys ludovicianus) with monkeypox virus are described. After intraperitoneal infection, all of the animals died within 11 days. Virus was cultured from their blood and oropharynx several days before death; at necropsy, most of the organs tested contained monkeypox virus. Marked hepatic and splenic necrosis were observed, along with mild inflammatory changes in the lungs. After intranasal (IN) infection, the primary pathologic changes were in the lungs and pleural cavity. Some of the IN infected animals (40%) survived, and monkeypox virus could be cultured from their nasal discharge and oropharynx for <22 days. Ulcerative lesions also developed on the lips, tongue, and buccal mucosa of the surviving animals. Our findings support an earlier report, which suggested that infected prairie dogs can transmit monkeypox virus by respiratory and mucocutaneous contact with susceptible animals and persons.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sciuridae
/
Monkeypox virus
/
Mpox
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article