Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity.
J Nat Prod
; 68(4): 611-3, 2005 Apr.
Article
em En
| MEDLINE
| ID: mdl-15844962
ABSTRACT
Parasite cGMP-dependent protein kinase (PKG) has been recently validated as a biochemical target for the treatment of coccidiosis. To discover new anticoccidial leads, we have screened our library of natural product extracts for inhibitors of parasite PKG. Bioassay-guided fractionation of the microbial extracts has led to the discovery of tenellones A (2) and B (3), two new highly substituted benzophenones. The isolation, structure, and activity of these compounds are described.
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Base de dados:
MEDLINE
Assunto principal:
Benzofenonas
/
Inibidores Enzimáticos
/
Fungos
Limite:
Animals
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article