The GABA type A receptor alpha5 subunit gene is associated with bipolar I disorder.
Neurosci Lett
; 381(1-2): 108-13, 2005.
Article
em En
| MEDLINE
| ID: mdl-15882799
ABSTRACT
Several genetic studies have revealed that bipolar disorders are linked with the chromosomal locus of 15q11-q13, where the gamma-aminobutyric acid (GABA) receptor alpha5 subunit gene (GABRA5) locates. GABA is one of the major neurotransmitters that may be involved in the pathogenesis of bipolar disorder. Five polymorphisms in the GABRA5 gene, -754C>T in the promoter region, IVS1-21G>A, IVS2-26T>A, (*)302C>T in 3'-UTR of exon 5, and a CA repeat polymorphism in the 3' flanking region were examined in a Japanese population. IVS1-21G>A exhibited significant differences in the distribution of the genotype and allele frequency in bipolar I disorder patients but not in bipolar II disorder patients, compared with control subjects. The haplotype analysis showed that IVS1-21G>A/IVS2-26A>T was associated with bipolar I disorder, and the IVS1-21A/IVS2-26T haplotype was a negative risk factor for susceptibility to the disorders (odds ratio 0.57, 95% confidence interval 0.44-0.73). These results suggest that the GABRA5 gene may confer susceptibility to bipolar I disorder.
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Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Transtorno Bipolar
/
Testes Genéticos
/
Receptores de GABA-A
/
Medição de Risco
/
Predisposição Genética para Doença
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article