Lsm proteins and RNA processing.
Biochem Soc Trans
; 33(Pt 3): 433-8, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-15916535
ABSTRACT
Sm and Lsm proteins are ubiquitous in eukaryotes and form complexes that interact with RNAs involved in almost every cellular process. My laboratory has studied the Lsm proteins in the yeast Saccharomyces cerevisiae, identifying in the nucleus and cytoplasm distinct complexes that affect pre-mRNA splicing and degradation, small nucleolar RNA, tRNA processing, rRNA processing and mRNA degradation. These activities suggest RNA chaperone-like roles for Lsm proteins, affecting RNA-RNA and/or RNA-protein interactions. This article reviews the properties of the Sm and Lsm proteins and structurally and functionally related proteins in archaea and eubacteria.
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Base de dados:
MEDLINE
Assunto principal:
RNA
/
Processamento Pós-Transcricional do RNA
/
Ribonucleoproteínas Nucleares Pequenas
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article