Primary dermal and eye irritability tests of hydrophobically modified hydroxypropyl methylcellulose in rabbits.
J Toxicol Sci
; 17(1): 21-9, 1992 Feb.
Article
em En
| MEDLINE
| ID: mdl-1593659
ABSTRACT
Primary dermal and eye irritation tests of hydrophobically modified hydroxypropyl methylcellulose (HM-HPMC, hydroxypropyl methylcellulose modified with stearylglycidylether), a new cellulose derivative used as a thickener for topical pharmaceuticals and cosmetics, were conducted in rabbits. A dispersion of HM-HPMC (3%) was applied to intact and abraded skins and reactions were observed. A very slight erythema was observed in both skins and this polymer was categorized as a "mild irritant". In the eye irritation test, with a dispersion of the same concentration, it was categorized as "marginal" in unrinsed eyes and "negative" in rinsed eyes.
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Base de dados:
MEDLINE
Assunto principal:
Pele
/
Celulose
/
Olho
/
Irritantes
Limite:
Animals
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article