A transcriptional repressor MeCP2 causing Rett syndrome is expressed in embryonic non-neuronal cells and controls their growth.
Brain Res Dev Brain Res
; 157(1): 103-6, 2005 Jun 09.
Article
em En
| MEDLINE
| ID: mdl-15939091
ABSTRACT
An epigenetic key protein MeCP2 is thought to be expressed exclusively in mature neurons. Here, we show that MeCP2 is expressed in embryonic non-neuronal cells by immunocytochemistry and Western blotting, and that knockdown of MeCP2 levels using RNA interference reduces their proliferation. These findings suggest that MeCP2 is essential to non-neuronal cell growth during brain development, which may be associated with microcephaly of Rett syndrome patients with MeCP2 mutations.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Proteínas Repressoras
/
Proteínas Cromossômicas não Histona
/
Síndrome de Rett
/
Córtex Cerebral
/
Neuroglia
/
Regulação da Expressão Gênica no Desenvolvimento
/
Proteínas de Ligação a DNA
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article