Structure-activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads.
Bioorg Med Chem Lett
; 15(15): 3632-6, 2005 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-15964758
ABSTRACT
Various heterocyclic hetero-methyl ketones of the 1-naphthyloxyacetyl-Val-Asp backbone have been prepared. A study of their structure-activity relationship (SAR) related to caspase-1, -3, -6, and -8 is reported. Their efficacy in a cellular model of cell death is also discussed. Potent broad-spectrum caspase inhibitors have been identified.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores de Cisteína Proteinase
/
Morte Celular
/
Inibidores de Caspase
/
Compostos Heterocíclicos
/
Cetonas
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article