A genetic linkage study of schizophrenia to chromosome 5 markers in a northern Italian population.
Biol Psychiatry
; 31(7): 720-8, 1992 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-1599988
ABSTRACT
Some recent findings report that the area 5q11.2-13.3 of chromosome 5 segregates with schizophrenia in an uncle-nephew pair (Bassett et al 1988). However, linkage studies between chromosome 5 markers loci and schizophrenia lead to different results:
Sherrington et al (1988) found a positive linkage, whereas other groups of researchers found evidence against linkage (Kennedy et al 1988; St. Clair et al 1989; Detera-Wadleigh et al 1989; McGuffin et al 1990; Aschauer et al 1990; Crowe et al 1991). We have studied five Italian pedigrees segregating schizophrenia using a map of four markers for the chromosomal region 5q11.2-13.3. Linkage analyses revealed negative lod scores, and thus no evidence for linkage was obtained in our Italian families.
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Base de dados:
MEDLINE
Assunto principal:
Esquizofrenia
/
Psicologia do Esquizofrênico
/
Cromossomos Humanos Par 5
/
Marcadores Genéticos
/
Ligação Genética
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article