Synergistic interaction of cyclosporin A and verapamil on vincristine and daunorubicin resistance in multidrug-resistant human leukemia cells in vitro.
Cancer Chemother Pharmacol
; 30(2): 152-4, 1992.
Article
em En
| MEDLINE
| ID: mdl-1600596
ABSTRACT
We studied the effects of cyclosporin A and verapamil on the modulation of vincristine and daunorubicin resistance in a multidrug-resistant subline of human T-cell acute lymphatic leukemia GM3639. Our results show that cyclosporin A is more effective than verapamil as a modulator of the high degree of primary vincristine resistance and the low degree of daunorubicin cross-resistance expressed by this cell line. Isobologram analysis revealed that the combined modulators act synergistically in correcting both vincristine and daunorubicin resistance.
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Base de dados:
MEDLINE
Assunto principal:
Vincristina
/
Verapamil
/
Leucemia-Linfoma de Células T do Adulto
/
Daunorrubicina
/
Ciclosporina
Limite:
Humans
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article