A reassessment of the Lewy body.
Acta Neurol Taiwan
; 14(2): 40-7, 2005 Jun.
Article
em En
| MEDLINE
| ID: mdl-16008161
ABSTRACT
Lewy body has been linked to Parkinson's disease for almost a century, but its significance in neurodegenerative diseases is not known. Whether it is toxic, protective, or just a bystander has been a subject of debate. Recent advances in molecular and genetic works suggest Lewy bodies are not essential for the diagnosis and pathogenesis of Parkinson's disease. Furthermore, the discovery of gene mutations in PARK8, an autosomal-dominant late-onset parkinsonism with pleomorphic pathology, suggests the clinical expression of neurodegenerative diseases depends more on the anatomical pathways affected rather than any particular "pathological marker".
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Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Corpos de Lewy
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article