[P-glycoprotein expression in radiation-associated acute myeloid leukemia].
Lik Sprava
; (3): 29-32, 2005.
Article
em Uk
| MEDLINE
| ID: mdl-16025673
ABSTRACT
The article presents findings of the analysis on P-glycoprotein expression of leukemic cells in 52 acute myeloid leukemia (AML) patients. Of these, there were 20 persons exposed to ionizing radiation due to the Chernobyl accident and 32 patients with spontaneous disease. Leukemic cells in patients with radiation-associated AML compared to spontaneous cases more often were P-glycoprotein positive (12/20 vs 9/32, P<0,05). P-glycoprotein overexpression significantly correlated with resistant disease in patients with radiation-associated AML, but was not a prognostic variable for treatment outcome in terms of overall survival.
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Base de dados:
MEDLINE
Assunto principal:
Leucemia Induzida por Radiação
/
Leucemia Mieloide
/
Membro 1 da Subfamília B de Cassetes de Ligação de ATP
/
Acidente Nuclear de Chernobyl
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País como assunto:
Europa
Idioma:
Uk
Ano de publicação:
2005
Tipo de documento:
Article