Tissue protection mediated by mitochondrial K+ channels.
Biochim Biophys Acta
; 1762(2): 202-12, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16026967
ABSTRACT
Two distinct K+ uniporters have been described in mitochondria, ATP-sensitive and Ca2+-activated. Both are capable of protecting tissues against ischemia and other forms of injury when active. These findings indicate a central role for mitochondrial K+ uptake in tissue protection. This review describes the characteristics of mitochondrial K+ uniport, physiological consequences of this transport, forms of tissue damage in which K+ channels are implicated and possible mechanisms through which protection occurs.
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Base de dados:
MEDLINE
Assunto principal:
Canais de Potássio
/
Citoproteção
/
Mitocôndrias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article