TGF-alpha, c-erbB-2 expression and neoangiogenesis in vulvar squamous cell carcinoma.
Anticancer Res
; 25(3A): 1731-7, 2005.
Article
em En
| MEDLINE
| ID: mdl-16033092
ABSTRACT
BACKGROUND:
TGF-alpha and c-erbB-2 are important mediators of tumor neoangiogenesis linked to the epidermal growth factor receptor. Thus, we analyzed TGF-alpha c-erbB-2 and tumor neoangiogenesis in vulvar carcinoma and determined their prognostic significance. PATIENTS ANDMETHODS:
Seventy-five carcinomas were evaluated for histological parameters. Tumors were stained immunohistologically for TGF-alpha, c-erbB-2 and factor VIII antigen. Results were analyzed statistically by chi2-test, Kaplan-Meier survival curves and log-rank-test.RESULTS:
Sixty-five % of the carcinomas were positive for TGF-alpha in >50% of the tumor cells. C-erbB-2 overexpression occurred in 47% of the tumors, but there was frequently a high cytoplasmatic staining. Twenty-nine % showed high microvessel densitiy. These tumors were more likely to have vascular space involvement (p=0.02). In carcinomas with TGF-alpha expression in >50% of the tumor cells, microvessel density was increased (p=0.05). Overall and disease-free survival tended to be reduced for tumors with high TGF-alpha expression and microvessel density, but differences were not significant.CONCLUSION:
Tumor neoangiogenesis is an important event in vulvar carcinogenesis which is related to the expression of growth factors.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Vulvares
/
Fator de Crescimento Transformador alfa
/
Receptor ErbB-2
/
Neovascularização Patológica
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article