Ion transport blockers inhibit human rhinovirus 2 release.
Antiviral Res
; 67(2): 98-106, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-16054245
ABSTRACT
Picornavirus replication causes leakage of cytoplasmic K+ and an influx of Na+ and Ca2+. In this study, we have explored the possibility that a blockade of Ca2+ and Na+ influx would reduce rhinovirus production and/or release. The Ca2+-channel blockers, verapamil and diltiazem, as well as the blocker of Na+/H+ exchange and the epithelial Na+ channel, EIPA, inhibited both virus production and release. The effect on virus release was more pronounced than the effect on production, thus raising the possibility that rhinovirus release may serve as a target for antiviral agents. Unexpectedly, our results also showed that the antiviral activity of the Ca2+-channel blockers was not due to the block of Ca2+ influx. Similarly, the antiviral activity of EIPA appeared to be unrelated to the blockade of cellular Na+/H+ exchanger or the epithelial Na+ channel. Potential alternative mechanisms of the antiviral activity of these compounds are discussed.
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Base de dados:
MEDLINE
Assunto principal:
Rhinovirus
/
Bloqueadores dos Canais de Cálcio
/
Transporte de Íons
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article