5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase.
Bioorg Med Chem Lett
; 15(19): 4226-9, 2005 Oct 01.
Article
em En
| MEDLINE
| ID: mdl-16055332
ABSTRACT
Starting from a 6,7-substituted quinazoline lead 4, optimisation of 5-substituted quinazolines containing an extended aniline motif led to potent and selective inhibitors of erbB2 receptor tyrosine kinase, and a representative compound 12a inhibited tumour growth in a mouse xenograft model.
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Base de dados:
MEDLINE
Assunto principal:
Quinazolinas
/
Proteínas de Transporte
/
Inibidores Enzimáticos
/
Antineoplásicos
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article