Does complement factor B have a role in the pathogenesis of atypical HUS?
Mol Immunol
; 43(7): 856-9, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16061287
ABSTRACT
Atypical haemolytic uraemic syndrome (aHUS) is a disorder of complement dysregulation. Because complement factor B (fB) carries the catalytic site of the alternative pathway convertase we examined it as both a potential candidate gene and modifier in the pathogenesis of aHUS. No factor B gene (BF) mutations were found in 20 patients with aHUS. There was no statistical difference between controls and aHUS patients in either BF allele or haplotype frequency. In conclusion, in this small series of aHUS patients we found no evidence that fB has a major role in the pathogenesis of aHUS.
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Base de dados:
MEDLINE
Assunto principal:
Fator B do Complemento
/
Síndrome Hemolítico-Urêmica
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article