Antenatal magnesium treatment and neonatal illness severity as measured by the Score for Neonatal Acute Physiology (SNAP).
J Matern Fetal Neonatal Med
; 17(2): 151-5, 2005 Feb.
Article
em En
| MEDLINE
| ID: mdl-16076625
ABSTRACT
OBJECTIVE:
. To determine if antepartum administration of magnesium sulfate affects the Score for Neonatal Acute Physiology (SNAP).METHODS:
We reviewed a database of consecutive preterm admissions to our neonatal intensive care unit over a 12-month period. Information on delivery indication, magnesium sulfate use, betamethasone administration, neonatal SNAP scores, neonatal serum magnesium levels, and other data was collected. Data was analyzed by Chi-square, Student t-test, and multiple linear regression with P < 0.05 considered significant.RESULTS:
During the study period, 221 cases fulfilled inclusion and exclusion criteria. Multiple regression revealed a significant association between antepartum magnesium use and improved SNAP scores after controlling for gestational age, glucocorticoid use, chorioamnionitis, and birthweight (SNAP score reduction = -2.25 +/- 0.78, P = 0.005).CONCLUSIONS:
Antepartum administration of magnesium sulfate results in a significant improvement in the neonatal SNAP score. These results suggest that antepartum magnesium sulfate may be protective, or at least not detrimental to the newborn infant.
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Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
/
Recém-Nascido Prematuro
/
Tocolíticos
/
Trabalho de Parto Prematuro
/
Sulfato de Magnésio
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article