Acute effects of guarana (Paullinia cupana Mart.) on mouse behaviour in forced swimming and open field tests.
Phytother Res
; 19(5): 441-3, 2005 May.
Article
em En
| MEDLINE
| ID: mdl-16106397
ABSTRACT
Guarana, a herbal extract from the seeds of Paullinia cupana Mart. has been evaluated in comparison with caffeine on mouse behaviour in forced swimming and open field tests. Guarana (25 and 50 mg/kg, p.o.) and caffeine (10 and 20 mg/kg, p.o.) each significantly reduced the duration of immobility in the forced swimming test suggesting an antidepressant-like effect in mice. At these doses, neither substance affected ambulation in the open field test. However, a high dose of guarana (100 mg/kg) and caffeine (30 mg/kg) significantly enhanced the locomotor activity in the open field test. Caffeine, but not guarana, could effectively block an adenosine agonist, cyclopentyl adenosine (CPA)-induced increase in swimming immobility suggesting that mechanism(s) other than the adenosinergic mechanism are involved in the antidepressant-like activity of guarana.
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Base de dados:
MEDLINE
Assunto principal:
Ansiolíticos
/
Comportamento Animal
/
Extratos Vegetais
/
Paullinia
/
Fitoterapia
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article