Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons.
Nat Neurosci
; 8(9): 1142-4, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16116455
ABSTRACT
Ablation of preBötzinger complex (preBötC) neurons, critical for respiratory rhythm generation, resulted in a progressive, increasingly severe disruption of respiratory pattern, initially during sleep and then also during wakefulness in adult rats. Sleep-disordered breathing is highly prevalent in elderly humans and in some patients with neurodegenerative disease. We propose that sleep-disordered breathing results from loss of preBötC neurons and could underlie death during sleep in these populations.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Centro Respiratório
/
Síndromes da Apneia do Sono
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Substância P
/
Imunotoxinas
/
Neurônios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article