Synthesis and SAR of highly selective MMP-13 inhibitors.
Bioorg Med Chem Lett
; 15(22): 4961-6, 2005 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-16153831
ABSTRACT
The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores Enzimáticos
/
Inibidores de Metaloproteinases de Matriz
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article