The influence of pH and temperature on the degradation kinetics of 4-methoxy-2-[3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c] pyridine in aqueous solutions.
Acta Pol Pharm
; 62(2): 83-8, 2005.
Article
em En
| MEDLINE
| ID: mdl-16161346
ABSTRACT
The pH-rate profiles for hydrolysis of 4-methoxy-2-[3-(4-phenyl-1-piperazinyl)]propyl-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c] pyridine (H) at 333, 343, 353 and 363 K over the pH range 0.4-5.0 was investigated. The decomposition was followed by the HPLC method (LiChrosorb 100 RP-18 column 250 x 4.0 mm I.D., dp = 5 microm; mobile phase acetonitrile-phosphate buffer (pH = 2; 0.01 mole/L) (45 55, v/v or 30 70, v/v). The pH-rate profile indicated specific acid- and base-catalysed reactions as well as spontaneous water-catalysed degradation of two molecules of II (as a dication and monocation). The ionic strength effect, the pKa value (2.4; 6.2), the pHmin value (2.1) and thermodynamic parameters of the reaction (energy and enthalpy of activation and the frequency coefficient for the specific rate constants) were determined.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Quinonas
/
Soluções
/
Água
/
Compostos Bicíclicos Heterocíclicos com Pontes
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article