Lymphatic vascular defects promoted by Prox1 haploinsufficiency cause adult-onset obesity.
Nat Genet
; 37(10): 1072-81, 2005 Oct.
Article
em En
| MEDLINE
| ID: mdl-16170315
ABSTRACT
Multiple organs cooperate to regulate appetite, metabolism, and glucose and fatty acid homeostasis. Here, we identified and characterized lymphatic vasculature dysfunction as a cause of adult-onset obesity. We found that functional inactivation of a single allele of the homeobox gene Prox1 led to adult-onset obesity due to abnormal lymph leakage from mispatterned and ruptured lymphatic vessels. Prox1 heterozygous mice are a new model for adult-onset obesity and lymphatic vascular disease.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Homeodomínio
/
Anormalidades Linfáticas
/
Metabolismo dos Lipídeos
/
Obesidade
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article