Verification of self-report of zygosity determined via DNA testing in a subset of the NAS-NRC twin registry 40 years later.
Twin Res Hum Genet
; 8(4): 362-7, 2005 Aug.
Article
em En
| MEDLINE
| ID: mdl-16176721
ABSTRACT
The National Academy of Sciences -- National Research Council (NAS-NRC) twin panel, created nearly 50 years ago, had twin zygosity determined primarily via a similarity questionnaire that has been estimated to correctly classify at least 95% of twins. In the course of a study on the genetics of healthy ageing in the NAS-NRC twins, DNA was collected for genome-wide scanning and zygosity confirmation was examined in 343 participating pairs. The sample was supplemented from two other studies using NAS-NRC twins where one or both co-twins were suspected to have Alzheimer disease or another dementia, or Parkinson's disease. Overall 578 twin pairs with DNA were analyzed. Zygosity assignment for 96.8% (519/536) was confirmed via questionnaire. Among 42 pairs whose questionnaire responses were inconclusive for assigning zygosity, 50% were found to be monozygous (MZ) and 50% were dizygous (DZ). There was some evidence for greater misclassification of presumed DZ pairs in the healthy ageing study where participation favored pairs who were similar in having a favorable health history and willingness to volunteer without any element of perceived risk for a specific disease influencing participation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Gêmeos Dizigóticos
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Gêmeos Monozigóticos
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DNA
Limite:
Adult
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Aged
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Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article