Indole-3-acetic acid antagonists of the prostaglandin D2 receptor CRTH2.
J Med Chem
; 48(20): 6174-7, 2005 Oct 06.
Article
em En
| MEDLINE
| ID: mdl-16190744
ABSTRACT
Prostaglandin D2 (PGD2) acting at the CRTH2 receptor (chemoattractant receptor-homologous molecule expressed on Th2 cells) has been linked with a variety of allergic and other inflammatory diseases. We describe a family of indole-1-sulfonyl-3-acetic acids that are potent and selective CRTH2 antagonists that possess good oral bioavailability. The compounds may serve as novel starting points for the development of treatments of inflammatory disease such as asthma, allergic rhinitis, and atopic dermatitis.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Prostaglandina
/
Receptores Imunológicos
/
Anti-Inflamatórios não Esteroides
/
Ácidos Indolacéticos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article