Malignant hypercalcemia in vulvar cancer.
Minerva Ginecol
; 57(5): 569-74, 2005 Oct.
Article
em En, It
| MEDLINE
| ID: mdl-16205603
ABSTRACT
Humoral hypercalcemia of malignancy (HHM) is a common paraneoplastic syndrome, most often associated with squamous cell carcinoma of the lung, esophagus, kidneys and breast, but rarely with vulval cancer. In most patients, HHM is associated with over-production of a peptide analogue of parathormone (parathyroid hormone-related protein, PTHrP). The case of a 70-year-old patient with massive squamous cell epithelioma of the vulva complicated by HHM is reported. To our knowledge, this is the first documented case with high serum concentrations of PTHrP and immunohistochemical confirmation of PTHrP production by neoplastic cells.
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Base de dados:
MEDLINE
Assunto principal:
Síndromes Paraneoplásicas
/
Neoplasias Vulvares
/
Carcinoma de Células Escamosas
/
Hipercalcemia
Limite:
Aged
/
Female
/
Humans
Idioma:
En
/
It
Ano de publicação:
2005
Tipo de documento:
Article