Expression of synaptic vesicle two-related protein SVOP in the developing nervous system of Xenopus laevis.
Dev Dyn
; 234(3): 802-7, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16217738
ABSTRACT
Synaptic vesicle-associated proteins are important regulators of neurotransmitter release at synaptic terminals in mature animals. Some synaptic vesicle-associated proteins are also expressed during development, although their contribution to development is not as clear. Here, we describe the cloning and developmental expression pattern of the Xenopus laevis synaptic vesicle-associated protein SVOP, a gene first identified as an immediate target for proneural basic helix-loop-helix factors. Alignment analysis revealed a high level of identity between the SVOP protein sequences from Xenopus and other vertebrates. In developing Xenopus embryos, SVOP expression is restricted to the nervous system and is first detectable at the mid-neurula stage. As development progresses SVOP becomes broadly expressed throughout the central nervous system. Our observation that SVOP is expressed in the developing Xenopus nervous system suggests that it may be involved in neuron formation, maturation, or neuronal function.
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Base de dados:
MEDLINE
Assunto principal:
Vesículas Sinápticas
/
Xenopus laevis
/
Regulação da Expressão Gênica no Desenvolvimento
/
Proteínas de Xenopus
/
Proteínas do Tecido Nervoso
/
Sistema Nervoso
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article