A new formulation concept for drugs with poor water solubility for parenteral application.
Pharmazie
; 60(9): 665-70, 2005 Sep.
Article
em En
| MEDLINE
| ID: mdl-16222865
ABSTRACT
The parenteral application of active substances with poor solubility in water is often bound to the use of stabilizing excipients or surfactants with serious undesired side effects. A new concept is introduced based on a drug concentrate, comprising the active substance dissolved in parenterally acceptable organic solvents, and an aqueous dilution medium, which are mixed in a special mixing device immediately prior to application and thus generating the applicable formulation directly prior to administration. Due to the requirement of formulation stability for only a few minutes, the amount of stabilizing agents can be reduced significantly. It can be shown that model drugs dissolved in a mixture of polyoxyethylen glycol, ethanol and soya lecithin as stabilizer may be mixed to an aqueous glucose solution resulting in a parenterally acceptable and administerable dispersion which is physically stable for several minutes. First in vivo data show good tolerability and blood plasma levels which are comparable to conventional solutions.
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Base de dados:
MEDLINE
Assunto principal:
Química Farmacêutica
/
Soluções Farmacêuticas
/
Composição de Medicamentos
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article