Structure and mechanism of DNA polymerases.
Adv Protein Chem
; 71: 401-40, 2005.
Article
em En
| MEDLINE
| ID: mdl-16230118
ABSTRACT
DNA polymerases are molecular motors directing the synthesis of DNA from nucleotides. All polymerases have a common architectural framework consisting of three canonical subdomains termed the fingers, palm, and thumb subdomains. Kinetically, they cycle through various states corresponding to conformational transitions, which may or may not generate force. In this review, we present and discuss the kinetic, structural, and single-molecule works that have contributed to our understanding of DNA polymerase function.
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Base de dados:
MEDLINE
Assunto principal:
DNA Polimerase Dirigida por DNA
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article