Chemical synthesis of oligonucleotides containing (M+4) guanine.
Nucleosides Nucleotides Nucleic Acids
; 24(5-7): 1081-3, 2005.
Article
em En
| MEDLINE
| ID: mdl-16248096
ABSTRACT
HPLC MS/MS has shown great potential in the measurement of DNA oxidative damage. Its accuracy depends on the use of multiply isotopically labelled internal standards. In this report, multiply isotopically labelled (M + 4) guanine internal standards were prepared in the form of base, nucleoside, as well as DNA oligomer. To our knowledge, this is the first chemical synthesis of oligomers containing (M + 4) guanine, and we believe that they can be used to develop a procedure that can make further improvement to the existing analytical procedures.
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Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Guanina
/
Biologia Molecular
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article