Total synthesis of reblastatin.
J Am Chem Soc
; 127(43): 15026-7, 2005 Nov 02.
Article
em En
| MEDLINE
| ID: mdl-16248632
Enantioselective total synthesis of reblastatin is described. The synthesis highlights hydrozirconation, transmetalation, aldehyde addition sequence to install E-trisubstituted olefin and C7 stereocenter, and the first use of an intramolecular Buchwald-like amidation reaction to close the 19-membered macrolactam.
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Base de dados:
MEDLINE
Assunto principal:
Quinonas
/
Antibacterianos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article