Claudins upregulation in human colorectal cancer.
FEBS Lett
; 579(27): 6179-85, 2005 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-16253248
ABSTRACT
In colorectal cancer tight junction molecular and morphological alterations are poorly understood. In this study, adenocarcinoma tissues and their paired normal mucosa (n = 12) were analyzed for tight junction alterations molecular. The expression of claudin-1, -3 and -4 was upregulated 5.7-, 1.5- and 2.4-fold, respectively, in colorectal tumor tissues in comparison to the normal ones. Although tight junction remains in the cancerous epithelium, its barrier function was altered. Despite claudins overexpression, paracellular permeability to ruthenium red was increased and a significant disorganization of tight junction strands was observed in freeze fracture replicas. Whereas the functional significance of claudin overexpression in colorectal cancer is unclear, these proteins can become potential markers and targets in colorectal cancer.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Adenocarcinoma
/
Regulação para Cima
/
Proteínas de Membrana
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article