Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material.
Pathol Res Pract
; 201(8-9): 599-602, 2005.
Article
em En
| MEDLINE
| ID: mdl-16259114
ABSTRACT
In this study, we describe a technique that allows for the production and the use of tissue microarrays (TMA) from HOPE-fixed, paraffin-embedded specimens. The combination of these two technologies unites the advantages of the high throughput aspects in TMA, with good preservation of nucleic acids, proteins, and morphology of HOPE-fixed tissues, thus substantially widening the capabilities presently available for molecular studies in paraffin-embedded tissues.
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Base de dados:
MEDLINE
Assunto principal:
Fixação de Tecidos
/
Inclusão em Parafina
/
Análise Serial de Tecidos
/
Fixadores
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article