Precise hit: adeno-associated virus in gene targeting.
Nat Rev Microbiol
; 3(11): 837-47, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16261169
ABSTRACT
Vectors based on the adeno-associated virus (AAV) have attracted much attention as potent gene-delivery vehicles, mainly because of the persistence of this non-pathogenic virus in the host cell and its sustainable therapeutic gene expression. However, virus infection can be accompanied by potentially mutagenic random vector integration into the genome. A novel approach to AAV-mediated gene therapy based on gene targeting through homologous recombination allows efficient, high-fidelity, non-mutagenic gene repair in a host cell.
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Base de dados:
MEDLINE
Assunto principal:
Dependovirus
/
Marcação de Genes
/
Vetores Genéticos
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article