Anti-cyclic citrullinated peptide antibodies in type 1 autoimmune hepatitis.
Aliment Pharmacol Ther
; 22(10): 951-5, 2005 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-16268969
ABSTRACT
BACKGROUND:
Besides the autoantibodies included in the diagnostic criteria of type 1 autoimmune hepatitis, many other autoantibodies have been described in this condition. Recently, antibodies against cyclic citrullinated peptide have been validated as specific diagnostic and prognostic markers of rheumatoid arthritis.AIM:
To assess whether these antibodies are part of the autoantibody repertoire of type 1 autoimmune hepatitis and correlate with rheumatological manifestations.METHODS:
Antibodies against cyclic citrullinated peptide were tested by a commercially available enzyme-linked immunosorbent assay.RESULTS:
The antibodies were found in 12 of 133 (9%) type 1 autoimmune hepatitis, two of 49 (4%) with primary biliary cirrhosis, one of 80 (1%) with hepatitis C virus-related chronic liver disease and 53 of 89 (60%) with rheumatoid arthritis serum samples. High titres were found only in rheumatoid arthritis and type 1 autoimmune hepatitis. No clinical (in particular rheumatological manifestations), biochemical or immunoserological differences were detectable between antibodies against cyclic citrullinated peptide positive and negative type 1 autoimmune hepatitis sera, with the exception of rheumatoid factor, always negative in the positive ones.CONCLUSIONS:
Antibodies against cyclic citrullinated peptide can be detected in a subgroup of patients with type 1 autoimmune hepatitis. They might be part of the wide range of autoantibody production characteristic of this condition and/or, less probably, be predictive of future rheumatoid arthritis development.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Autoanticorpos
/
Doenças Autoimunes
/
Anticorpos Anti-Hepatite
/
Hepatite
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Child, preschool
/
Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article