HLA class II and response to interferon-beta in multiple sclerosis.
Acta Neurol Scand
; 112(6): 391-4, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16281922
ABSTRACT
OBJECTIVE:
To study the relationship between human leucocyte antigen (HLA) genotype and clinical response to interferon-beta (IFN-beta).METHODS:
We analysed the HLA class II genotypes of 96 multiple sclerosis (MS) patients treated with IFN-beta. The patients were classified as responders or non-responders according to clinical criteria one or more relapses or a sustained increase after 1 year treatment compared with the year prior to IFN-beta therapy of > or = 0.5 points on the Expanded Disability Status Scale (EDSS).RESULTS:
There were 66 (69%) responders and 30 (31%) non-responders. Baseline clinical characteristics were similar. We found no association between HLA class II alleles and clinical response to IFN-beta.CONCLUSIONS:
HLA genotype does not appear to influence the clinical response to IFN-beta in MS patients.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe II
/
Interferon beta
/
Genótipo
/
Esclerose Múltipla
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article