The relationship between condom use and herpes simplex virus acquisition.
Ann Intern Med
; 143(10): 707-13, 2005 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-16287791
ABSTRACT
BACKGROUND:
Few studies have evaluated the relationship between condom use and herpes simplex virus type 2 (HSV-2) and HSV type 1 (HSV-1) acquisition.OBJECTIVE:
To assess the relationship between condom use and acquisition of HSV-2 and HSV-1 among men and women.DESIGN:
Analysis of data collected as part of a clinical trial of an ineffective candidate vaccine for HSV-2.SETTING:
Sexually transmitted disease clinics.PARTICIPANTS:
Men and women at risk for HSV-2 acquisition, defined as having 4 or more sexual partners or having a sexually transmitted disease in the past year. MEASUREMENT Acquisition of HSV-2 and HSV-1 as measured by viral culture or change to positive HSV serostatus.RESULTS:
Of 1843 participants, 118 (6.4%) became infected with HSV-2. In multivariate analyses, participants reporting more frequent use of condoms were at lower risk for acquiring HSV-2 than participants who used condoms less frequently (hazard ratio, 0.74 [95% CI, 0.59 to 0.95]); categories of increasing condom use were 0% to 25%, 25% to 75%, and greater than 75% of sexual acts. Nineteen (2.9%) of 659 participants at risk for infection with HSV-1 became infected. No statistically significant association between condom use and infection with HSV-1 was found (hazard ratio, 0.79 [CI, 0.48 to 1.31]).LIMITATIONS:
Use of condoms was measured by self-report, and persons who used condoms may have differed from those who did not.CONCLUSIONS:
Consistent use of condoms is associated with lower rates of infection with HSV-2 and should be routinely recommended.
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Base de dados:
MEDLINE
Assunto principal:
Herpes Genital
/
Preservativos
/
Herpesvirus Humano 2
/
Herpesvirus Humano 1
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article