AIDS restriction HLA allotypes target distinct intervals of HIV-1 pathogenesis.
Nat Med
; 11(12): 1290-2, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16288280
ABSTRACT
An effective acquired immune response to infectious agents mediated by HLA-restricted T-cell recognition can target different stages of disease pathogenesis. We show here that three distinct HLA alleles known to alter the overall rate of AIDS progression act during distinct intervals after HIV-1 infection. The discrete timing of HLA allele influence suggests alternative functional mechanisms in immune defense against this dynamic and chronic immunosuppressive disease.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos HLA-B
/
Síndrome da Imunodeficiência Adquirida
/
HIV-1
/
Linfócitos T CD8-Positivos
/
Alelos
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article