Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice.
Vision Res
; 46(5): 688-98, 2006 Mar.
Article
em En
| MEDLINE
| ID: mdl-16289664
ABSTRACT
We studied electrophysiological properties of cultured retinal pigment epithelial (RPE) cells from mouse and a mouse model for Norrie disease. Wild-type RPE cells revealed the expression of ion channels known from other species delayed-rectifier K(+) channels composed of Kv1.3 subunits, inward rectifier K(+) channels, Ca(V)1.3 L-type Ca(2+) channels and outwardly rectifying Cl(-) channels. Expression pattern and the ion channel characteristics current density, blocker sensitivity, kinetics and voltage-dependence were compared in cells from wild-type and Norrie mice. Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models.
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Base de dados:
MEDLINE
Assunto principal:
Epitélio Pigmentado Ocular
/
Oftalmopatias Hereditárias
/
Canais Iônicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article