Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents.
Bioorg Med Chem
; 14(6): 1851-62, 2006 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-16289857
ABSTRACT
The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.
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Base de dados:
MEDLINE
Assunto principal:
Alilamina
/
Antifúngicos
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article