New class of competitive inhibitor of bacterial histidine kinases.
J Bacteriol
; 187(23): 8196-200, 2005 Dec.
Article
em En
| MEDLINE
| ID: mdl-16291694
ABSTRACT
Bacterial histidine kinases have been proposed as targets for the discovery of new antibiotics, yet few specific inhibitors of bacterial histidine kinases have been reported. We report here a novel thienopyridine (TEP) compound that inhibits bacterial histidine kinases competitively with respect to ATP but does not comparably inhibit mammalian serine/threonine kinases. Although it partitions into membranes and does not inhibit the growth of bacterial or mammalian cells, TEP could serve as a starting compound for a new class of histidine kinase inhibitors with antibacterial activity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases
/
Piridinas
/
Proteínas de Bactérias
/
Inibidores Enzimáticos
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article