Factors of importance for a successful delivery system for proteins.
Expert Opin Drug Deliv
; 2(6): 1029-37, 2005 Nov.
Article
em En
| MEDLINE
| ID: mdl-16296807
ABSTRACT
Protein pharmaceuticals have matured into an important class of drugs, now comprising one in three novel drugs introduced on the market. However, significant gains are still to be made in reducing the costs of production, ensuring proper pharmacokinetics and efficacy, increasing patient compliance and convenience, and reducing side effects such as immunogenicity. This review summarises these issues and provides recent examples of methods to reduce costs, alter pharmacokinetics and increase patient compliance. It also discusses the increasing interest in understanding immunogenicity in order to prevent failure of the protein drug or serious life-threatening side effects due to autoimmunogenicity.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Sistemas de Liberação de Medicamentos
/
Estabilidade de Medicamentos
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2005
Tipo de documento:
Article