Intracellular nucleotides of lymphocytes and granulocytes from normal ageing subjects.
Mech Ageing Dev
; 64(1-2): 1-11, 1992 Jun.
Article
em En
| MEDLINE
| ID: mdl-1630150
ABSTRACT
Impaired lymphocyte and granulocyte function in the aged may, in part, reflect intrinsic aged-related biochemical alterations. In this study we compared the ribonucleotide contents of lymphocytes and granulocytes from young and old subjects evaluated by means of an HPLC-anion exchange method. We found that in general both populations from old subjects present higher levels of the various nucleotides, in particular ATP, UDP, CTP, UDP-glucose in granulocytes, AMP, CTP, UDP-N-acetylglucosamine, UDP-glucose in lymphocytes. These data suggest that these molecules accumulate in aged subjects because of altered biochemical pathways. The increased pool of UDP-sugars, in particular, could be due to a depressed activity of some glycosyltransferases which therefore fail to glycosylate some plasma membrane cell proteins, thus accounting for their functional impairment.
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Base de dados:
MEDLINE
Assunto principal:
Ribonucleotídeos
/
Envelhecimento
/
Linfócitos
/
Granulócitos
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1992
Tipo de documento:
Article